Skin is the largest organ of the human body and comprises three major layers: epidermis, dermis, and the subcutaneous layers. One vital function of the skin is to form an effective barrier between the organism and the environment. It maintains an ‘inside-outside’ barrier, regulating water loss, and an ‘outside-inside’ barrier, protecting the organism from external harm including mechanical, chemical, and microbial. A disrupted barrier function exposes the skin to pathogenic bacteria and also compromises the skin’s homeostasis.
In this lecture you will learn: